Developments in osteoarthritis
نویسندگان
چکیده
منابع مشابه
Developments in osteoarthritis.
Perhaps the most important change in OA over the past 60 years has been in attitudes rather than knowledge. OA has changed from being a boring, degenerative form of joint pathology, for which nothing could be done [1, 2], to an exciting clinical disorder of the joints that can be manipulated and improved [3, 4]. Unfortunately, that change has yet to be fully embraced or understood by all the he...
متن کاملDevelopments in the clinical understanding of osteoarthritis
With the recognition that osteoarthritis is a disease of the whole joint, attention has focused increasingly on features in the joint environment which cause ongoing joint damage and are likely sources of pain. This article reviews current ways of assessing osteoarthritis progression and what factors potentiate it, structural abnormalities that probably produce pain, new understandings of the g...
متن کاملDevelopments in the scientific understanding of osteoarthritis
Osteoarthritis is often a progressive and disabling disease, which occurs in the setting of a variety of risk factors--such as advancing age, obesity, and trauma--that conspire to incite a cascade of pathophysiologic events within joint tissues. An important emerging theme in osteoarthritis is a broadening of focus from a disease of cartilage to one of the 'whole joint'. The synovium, bone, and...
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Joint trauma can lead to a spectrum of acute lesions, including osteochondral fractures, ligament or meniscus tears and damage to the articular cartilage. This is often associated with intraarticular bleeding and causes posttraumatic joint inflammation. Although the acute symptoms resolve and some of the lesions can be surgically repaired, joint injury triggers a chronic remodeling process in c...
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PURPOSE OF REVIEW Despite the tremendous individual suffering and socioeconomic burden caused by osteoarthritis, there are currently no effective disease-modifying treatment options. This is in part because of our incomplete understanding of osteoarthritis disease mechanism. This review summarizes recent developments in therapeutic targets identified from surgical animal models of osteoarthriti...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2011
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/keq373